Forma, Vol. 15 (No. 4), pp. 393-407, 2000
Original Paper

Cell Sorting Model Based on Cell Signaling

Takuya T. Maeda

Department of Physics, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan

(Received December 7, 1999; Accepted February 26, 2000)

Keywords: Cell Sorting, Morphogenesis, Individual-Based Model

Abstract. We propose a model for cell sorting which accounts for a key phenomenon of histogenesis and morphogenesis. The model reproduces almost all the characteristics of cell rearrangements seen in experimental observations of cell sorting. In particular, global patterns, internal and external positions of an aggregate, seen in cell sorting are reproduced based only on local interactions among the nearest neighbor cells. The model assumes autonomous cell activity, which includes cell communication and active cell movement. The assumptions are fit for current understanding of cell behavior in cell biology, while cell sorting has been discussed based on cell adhesion. Our model gives us not only a consistent explanation for the process of cell sorting, but also a perspective on the development process.

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